Dave Feldman
Dave Feldman
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Old Biology Meets New Technology – Raphael Sirtoli – #CoSci
Raphael Sirtoli's presentation delves into the intersection of ancestral health principles and self-experimentation, focusing on a new health-tracking app called Ancestral. The app aims to improve users' health by estimating disease probabilities using a Bayesian network and suggesting interventions based on low-carb, ketogenic, and carnivore diets, among other lifestyle changes. Sirtoli highlights the importance of evolutionary biology in understanding health, advocating for self-experimentation and skepticism of mainstream medical advice. He emphasizes the distinction between common and normal health conditions and criticizes the conventional medical approach for ignoring evolutionary biology and promoting surface-level symptom treatment.
Chapter List
0:00 - Introduction and Background
0:27 - Opening Remarks
0:50 - Ancestral Health Principles
1:21 - Overview of Ancestral App
2:01 - Statistical Bayesian Network
2:24 - Roadmap of the Talk
3:00 - Causal Connections and Disease Modeling
4:18 - Estimating Disease Risk
4:52 - Menu of Interventions
5:52 - Importance of Tracking Progress
6:48 - Education and Explanation of Interventions
7:00 - Philosophical Overlap with Citizen Science Foundation
8:01 - Hashtag #DoYourOwnResearch
9:00 - Common vs. Normal Health Conditions
9:50 - Evolutionary Biology and Self-Experimentation
10:47 - Differences of Ancestral from Mainstream Medicine
12:00 - Simplified Model of Insulin Resistance
12:50 - Evolutionary Biology in Medicine
13:50 - Root Cause Analysis vs. Symptom Analysis
14:48 - Conclusion and Favorite Quote
Переглядів: 1 257

Відео

Myths & Misconceptions of Insulin Resistance - Ben Bikman - #CoSci
Переглядів 33 тис.14 днів тому
Dr. Ben Bikman, a specialist in bioenergetics and insulin's role in metabolic disorders, presents a comprehensive talk on insulin resistance. He highlights the rising prevalence of insulin resistance and its impact on various chronic diseases. Bikman stresses the importance of precise terminology and understanding of insulin resistance, differentiating between its pathological and physiological...
Confronting Bias with Data - Jeremy Malecha - #CoSci
Переглядів 1,5 тис.21 день тому
Jeremy Malecha, CEO and co-founder of Biocanic, presents his journey and vision for healthcare integration through functional medicine. Malecha shares his personal health journey, detailing his experience with various health challenges and the role functional health practices played in his recovery. He discusses the use of advanced diagnostics, personalized health data, and health intelligence ...
Respectful Reaction: Nick's ApoB vs All Cause Mortality
Переглядів 13 тис.21 день тому
In this video, I react to a preview video from Nick Norwitz (UA-cam.com/@UCLTZUJSEulehPtF_ytFiU_A ) discussing LDL and Apolipoprotein B (ApoB) and its relevance to cardiovascular risk and all-cause mortality. @nicknorwitzPhD 's video: ua-cam.com/video/sAjDjLJUlQQ/v-deo.html
A Tale of Two Sugars - Dr Richard Johnson - #CoSci
Переглядів 40 тис.21 день тому
Dr. Richard Johnson, a renowned professor of medicine, delves into the biological mechanisms behind obesity and related diseases in his presentation, "A Tale of Two Sugars." He explores the impact of fructose, a type of sugar found in fruit and added sugars, on metabolic health and how it drives conditions such as diabetes, obesity, and Alzheimer's disease. Johnson explains how fructose trigger...
Keto for ADHD, Anxiety, Depression, and Autism in Children - Carlos Barrios MD - #CoSci
Переглядів 2,2 тис.28 днів тому
In his presentation, Dr. Carlos Barrios discusses the integration of metabolic and functional principles in psychiatry, with a focus on child and adolescent psychiatry. He emphasizes the importance of medication independence through dietary interventions. Dr. Barrios shares his personal health journey, overcoming throat cancer and various health issues through diet changes, specifically transit...
Writing With the Wrong Letters - Amber O'Hearn - #CoSci
Переглядів 9 тис.Місяць тому
Summary Amber O'Hearn's presentation provides an in-depth look into her personal journey and contributions to the field of diet and nutrition, particularly the carnivore diet. She discusses her unconventional path through academia, her struggles with depression, and how adopting a low-carb and subsequently a carnivore diet transformed her health and career. O'Hearn highlights the importance of ...
Three words that changed my life: "I have Cancer" - Michelle Hurn - #CoSci
Переглядів 9 тис.Місяць тому
Michelle Hurn, a registered dietitian and ultrarunner, discusses the impact of an animal-based ketogenic diet on cancer treatment, drawing from her personal experience with her wife's cancer diagnosis. Hearn emphasizes the potential of metabolic therapy in addressing cancer, contrasting it with conventional genetic mutation-focused treatments. She shares her journey of implementing a strict ket...
Is MVX the New Frontier in Predicting All Cause Mortality? - Dr. William Cromwell - #CoSci
Переглядів 8 тис.Місяць тому
Dr. William Cromwell discusses the complex interaction of metabolic and inflammatory factors in determining mortality risks, beyond traditional cardiovascular risk factors. He introduces the concept of the Metabolic Vulnerability Index (MVX), which combines six biomarkers to better predict mortality risks in various populations. His studies illustrate that mortality can be significantly predict...
Picture of Health? Not so Fast - Darius Sharpe - #CoSci
Переглядів 7 тис.Місяць тому
CoSci (Collaborative Science Conference) is a charity fundraising event to raise money for the Citizen Science Foundation. Please consider making a tax-deductible donation to CitizenScienceFoundation.org/donate - and thank you for your support. Summary: Darius Sharpe, an experienced ER nurse and former paramedic, shares his unexpected journey discovering his own heart disease despite leading a ...
Match Analysis of High LDL on Keto - Matthew Budoff - #CoSci
Переглядів 28 тис.2 місяці тому
CoSci (Collaborative Science Conference) is a charity fundraising event to raise money for the Citizen Science Foundation. Please consider making a tax-deductible donation to CitizenScienceFoundation.org/donate - and thank you for your support. Dr. Matthew Budoff presented the #CoSci keynote on the use of CT angiography to measure atherosclerotic plaque and evaluate the effects of a ketogenic d...
LDL Cholesterol Debate - William Cromwell, Bret Scher, Nadir Ali - #CoSci
Переглядів 66 тис.2 місяці тому
This panel discussion/debate took place at CoSci (Collaborative Science Conference), a charity fundraising event to raise money for the Citizen Science Foundation - on March 16, 2024 in Las Vegas, NV. Please consider making a tax-deductible donation to CitizenScienceFoundation.org/donate - and thank you for your support.
From Suffering to Science: Fixing LADA with - Jessica Apple - #CoSci
Переглядів 8 тис.2 місяці тому
From Suffering to Science: Fixing LADA with - Jessica Apple - #CoSci
When Is a Diet Not a Diet? - Bret Scher - #CoSci
Переглядів 43 тис.2 місяці тому
When Is a Diet Not a Diet? - Bret Scher - #CoSci
Does Dopamine Drive Food Addiction? - Dr. Nadir Ali - #CoSci
Переглядів 7 тис.2 місяці тому
Does Dopamine Drive Food Addiction? - Dr. Nadir Ali - #CoSci
Keto Reversing Bipolar? - #CoSci - Matt Baszucki
Переглядів 3,9 тис.3 місяці тому
Keto Reversing Bipolar? - #CoSci - Matt Baszucki
Chatting with Dr. William Cromwell on the #OreoVsStatin Experiment
Переглядів 14 тис.5 місяців тому
Chatting with Dr. William Cromwell on the #OreoVsStatin Experiment
Biggest impact on cholesterol with Keto - Saturated Fat or BMI? Our new paper makes a powerful case
Переглядів 29 тис.5 місяців тому
Biggest impact on cholesterol with Keto - Saturated Fat or BMI? Our new paper makes a powerful case
Yes, 2024 is the game changing moment we've waited for - Here's why in 5 Minutes
Переглядів 30 тис.5 місяців тому
Yes, 2024 is the game changing moment we've waited for - Here's why in 5 Minutes
Response Video to Mic the Vegan - Part 2
Переглядів 15 тис.5 місяців тому
Response Video to Mic the Vegan - Part 2
Response Video to Mic the Vegan - Part 1
Переглядів 23 тис.5 місяців тому
Response Video to Mic the Vegan - Part 1
Come Speak at Our Conference! (A Call to All Citizen Scientists)
Переглядів 1,1 тис.5 місяців тому
Come Speak at Our Conference! (A Call to All Citizen Scientists)
Join Us at Our Fundraising Conference in Las Vegas!
Переглядів 1,4 тис.6 місяців тому
Join Us at Our Fundraising Conference in Las Vegas!
BREAKING - New Analysis of Heart Scan Data (CCTA) for Extremely high LDL vs Average LDL Cholesterol
Переглядів 77 тис.6 місяців тому
BREAKING - New Analysis of Heart Scan Data (CCTA) for Extremely high LDL vs Average LDL Cholesterol
BREAKING - Match Analysis on LMHR Study Released
Переглядів 48 тис.6 місяців тому
BREAKING - Match Analysis on LMHR Study Released
A Simple Analogy to Explain High ApoB and Why LMHR May Be Different
Переглядів 34 тис.6 місяців тому
A Simple Analogy to Explain High ApoB and Why LMHR May Be Different
Is there something different about high LDL on Keto? Why LMHRs may have the answer.
Переглядів 19 тис.6 місяців тому
Is there something different about high LDL on Keto? Why LMHRs may have the answer.
Catching Up: Rogan Reveal, CSF Conference, Budoff's Big Presentation
Переглядів 3,9 тис.6 місяців тому
Catching Up: Rogan Reveal, CSF Conference, Budoff's Big Presentation
Doctors discuss ApoB and Insulin resistance - Can Models account for LMHRs?
Переглядів 11 тис.8 місяців тому
Doctors discuss ApoB and Insulin resistance - Can Models account for LMHRs?
New Exogenous Ketone Could Open Doors in Research
Переглядів 4,4 тис.11 місяців тому
New Exogenous Ketone Could Open Doors in Research

КОМЕНТАРІ

  • @lizakiesling1289
    @lizakiesling1289 2 години тому

    Keto diet 5 years 67 female 2021 CAC scan 24. Feb 2024 148 mostly LAD. Always high cholesterol , controlled type 2 diabetes, under 150 triglycerides.

  • @haydeeramos7839
    @haydeeramos7839 6 годин тому

    DR Ali. Thank you for those wonderful explanations ❤

  • @bryanspencer4856
    @bryanspencer4856 15 годин тому

    So even though we’ve literally NEVER observed evolution, we’re going to base science on evolution. Foolish.

  • @WarrenRedlich
    @WarrenRedlich 18 годин тому

    So how does a regular individual get the tests needed to calculate MVX?

  • @stayingstrong57
    @stayingstrong57 День тому

    (I am 66 years old)I was on statins because of high ldl until 6 months ago. I stopped the statins and tested 4 months later. . Very scared of what the doctor might say to me on my next visit! Are there any other tests I should get? I wonder if I am a LMHR? (Total Cholesterol 285 LDL-C 167 HDL 111 TG 49). APO B 110 Fasting Insulin 4.0 Fasting Glucose 84 HOMA-IR 0.83. LPa 28.7 nmoL/L CAC score 27 BMI 20

  • @TheMoQingbird
    @TheMoQingbird День тому

    @13:30 sums up every visit to a medical professional I have ever had.

  • @A99286
    @A99286 2 дні тому

    There's no app in Play Store, send link

    • @jobrown8146
      @jobrown8146 День тому

      I looked for it too and cannot find it. I even did a search for it on my computer and included the term health tracking and couldn't find anything about it. Perhaps they are still getting it up and running.

    • @sArAh-dj1xw
      @sArAh-dj1xw День тому

      1:27 minutes in: "It should be out in 2025."

    • @jobrown8146
      @jobrown8146 День тому

      @@sArAh-dj1xw I and the OP obviously didn't hear that. Thanks for letting us know.

  • @ucchi9829
    @ucchi9829 2 дні тому

    21:15 "challenging" is wild. All you did was make cringe statements about study design which you know so little about.

  • @ucchi9829
    @ucchi9829 2 дні тому

    Dr Nadir has no clue how clinical trials work lmao.

  • @luciavasile2895
    @luciavasile2895 2 дні тому

    Awesome👌🤙🏻👍🫶💪

  • @JBlynx88
    @JBlynx88 2 дні тому

    Wonderful presentation.

  • @roryfaherty4375
    @roryfaherty4375 2 дні тому

    Amazing story. Don't know if the algorithms are firing overload or pharma knows that Keto is effective. Right after watching the presentation The Bipolar drug adds kicked in " LYBALVI" . They just gotta get those pills into ya. The overreliance on the chemical pathway as being the only way to treat whether psychiatric or metabolic diseases is such an anecdotal fallacy.

  • @mikeyfazed
    @mikeyfazed 3 дні тому

    I wonder who the "knuckle heads" Dr Bikman means at 16:20 are... He seems like such a nice guy, never seen him get so worked up!!

  • @tiffinywilliams5055
    @tiffinywilliams5055 3 дні тому

    Thank you so much for sharing your story! I am going to share this with friends who work in the mental health field! 😀

  • @shevawnprather7162
    @shevawnprather7162 3 дні тому

    Dr. Ali speaks the truth. We don’t need more knowledge, we need more wisdom in this world!

  • @shevawnprather7162
    @shevawnprather7162 3 дні тому

    To big food, big pharma and many others that benefit big time financially from our ills, shame on you! Simply eat a clean whole food diet, fast in between, get plenty of exercise and good sleep. God will take care of the rest. No pills required! ❤️

  • @ceeemm1901
    @ceeemm1901 4 дні тому

    So if I follow Amber's diet, do you promise that I'll look wonderfully fat and haggard like her too?

  • @DennisForbes
    @DennisForbes 4 дні тому

    It is unfortunate that videos like this invariably have comments that overwhelmingly are filled with "the guy who has a position that conforms with my bias -- one usually driven by situation and hope -- is the best and super won". It's useless, and if you aren't seek out information challenging your existing beliefs, but instead are looking to reframe everything as validation, you are fooling yourself.

  • @1xm_mx1
    @1xm_mx1 4 дні тому

    Very good analogy. I can understand the process better now.

  • @sharonillenye8036
    @sharonillenye8036 6 днів тому

    great talk! we have to all learn to advocate and get personalized medicine (n=1). I just found out i have high LPa so now I have to rethink everything I'm doing by myself because my dr just wants pcsk9i now that I quit my statin after 4 years. I also bought a glucose monitor and its very interesting , hopefully cgm come down in price some time.

  • @pureabsolute4618
    @pureabsolute4618 6 днів тому

    Very nice - and thank you Dave! One thing that surprised me is that not even Dr. Nadir brought up the potential distinction between LDL, and LDL that's been Glycated or Oxidized. An LDL count that does not distinguish these types means even normal LDL that has a function is included in the measurement. I need to know: Does reducing "small ldl" (for lack of a better description - Both oxidization and glycation reduce the size of the LDL molecule) cholesterol while keeping normal LDL high either cause more plaque growth, or even reverse or reduce the plaques? This hypothesis has been around for about 5 years.

  • @willbrink
    @willbrink 6 днів тому

    Very low ApoB levels in adults likely indicates disease, usually cancer, but not always. Data is mixed, but the bulk of the data indicates lower ApoB the better for ASCVD and ACM. Those who ignore their ApoB levels are likley making a serious mistake, but it's certainly not the only lab to track. We also have large studies that consistently find inflammation, as measured by hsCRP is more predictive of ASCVD than LDLc. Not sure about ApoB and ACM, but have not looked recently. Studies usually find longevity is associated with lower inflammation, which makes sense. It also makes sense a multi marker index will be more accurate then any single marker to predict ACM, and development of multi markers will give a better and bigger picture of metabolic health.

  • @dennisward43
    @dennisward43 6 днів тому

    If only mic the vegan would hold the weak, plant biased studies he quotes ad nauseam to a similar critique.

  • @Roberto-cg2gr
    @Roberto-cg2gr 6 днів тому

    When will this be published?

  • @csmrfx
    @csmrfx 7 днів тому

    Very kind of you to share this, Mr. Feldman. Much appriciated! 💎

  • @northyland1157
    @northyland1157 7 днів тому

    I have type 2 diabetes. I went low carb, then keto. I skip breakfast. I stopped insulin and never took other meds. My overnight fasting insulin is 95. After meals I hit 122 If i don't exercise, about 89 if I do, which is most of the time. If I fast for 2 or 3 days my BG goes as low as 60.

  • @stevenmeek9
    @stevenmeek9 7 днів тому

    Can you please cover the Randle Cycle?

  • @M.Sforza
    @M.Sforza 8 днів тому

    This man is a gift to us with metabolic challenges. Thank you Sir!

  • @utopiadweller
    @utopiadweller 8 днів тому

    20:05

  • @tracysnider6922
    @tracysnider6922 8 днів тому

    I've been keto for 4 1/2 years. My ldl is always high - freaking my Dr out, who orders Calcium scores on me and every time it comes back zero.

  • @huffhouseart3377
    @huffhouseart3377 8 днів тому

    Just subscribed, been believing all you've advised, snd feel better than i have for many years thanks.

  • @keithbertschin1213
    @keithbertschin1213 8 днів тому

    Don’t encourage him with the god stuff pleeeeease

  • @Ikr2025
    @Ikr2025 8 днів тому

    My mother would have grown up on a VERY healthy diet with probably almost zero fast food, seed oils or excess sugar. She was very slim in her 20s. But from her 30s on she steadily gained weight and now in her 80s is obese, has arthritis, lipedema and struggles to walk very far. I don’t think her diet as a teen really has been much of a reflection of her health as an adult. She also never smoked or even drank alcohol as an adult. My husband also would not have eaten much sugar, or fast food - but he now has type 2 diabetes similar to his father and brother. Genetics does seem to play a part.

    • @ilovepineapples2
      @ilovepineapples2 8 днів тому

      Ketogenic diets would help both of them immensely

  • @semarugaijin9451
    @semarugaijin9451 9 днів тому

    The problem with this metabolic theory is I never hear any actionable take away, what should eat? It sounds to me luke what he is saying is that early life stress and hormonal changes are really what get the ball rolling and once it starts theres really no stopping it amd that fits my experience. At the end he talks about giving his kids a body that they will either "enjoy, or fight against for the rest of their lives" ... I guess I have one that I have to fight against 😢

    • @Ikr2025
      @Ikr2025 8 днів тому

      I don’t believe that. My brother grew up eating a tonne of bread, milk and cereal as a teen. He grew v tall has had good health for the majority of his adult life, never v overweight, lots of energy. I grew up in the same household, didn’t eat nearly as much bread, though did eat more sugary snacks - but they’re all made of the same stuff at the end of the day, didn’t grow v tall, got the same mild lipedema issue as my mother and have struggled with my health and energy levels. A lot is due to genetics imo!

  • @yosefsugi1808
    @yosefsugi1808 9 днів тому

    ❤❤❤❤

  • @themuleify
    @themuleify 9 днів тому

    While Dr. Rick Johnson is 'not' trying hard to promote Allulose, I wonder under how big of a rock he will be crawling when in a few years a new study comes out showing Allulose correlation to heart attacks.😂

  • @SG-ji5ij
    @SG-ji5ij 9 днів тому

    I notice that these issues trend more closely with wireless device usage than anything else.

  • @bonnieschmidt5882
    @bonnieschmidt5882 9 днів тому

    Or maybe the message should be that we just don’t need to eat as much sugar?